Osteoarthritis treatment vitamin d

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  • What is osteoarthritis, and what are the symptoms?
  • VItamin D Effect on Osteoarthritis Study (VIDEO)
  • Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial
  • Ways to Give
  • What is osteoarthritis, and what are the symptoms?

    Conventional treatment is palliative and costly, and currently there are no effective medical remedies for OA. Age, body mass index, and female sex were positively associated with the prevalence. Strong evidence for an association between OH D and cartilage loss was apparent when joint space narrowing and changes in cartilage volume were considered collectively as cartilage loss. Zang and colleagues investigated serum concentrations of vitamin D hydroxyvitamin D [25 OH D] and the parathyroid hormone which regulates vitamin D in order to predict knee osteoarthritis progression 5. Arthritis Rheum. VolumeIssue 12, pp.

    Osteoarthritis treatment vitamin d

    Association between serum vitamin D deficiency and knee osteoarthritis Int Orthop. Epub Dec J Orthop Sci. Epub Dec 8. Age, body mass index, and female sex were positively associated with the prevalence. Among the dietary factors, only vitamin K intake was shown to be inversely associated with the prevalence of radiographic knee OA by multivariate logistic regression analysis. The presence of joint space narrowing of the knee was also inversely associated with vitamin K intake.

    The prevalence of radiographic knee OA for each dietary vitamin K intake quartile decreased with the increased intake. Vitamin K may have a protective role against knee OA and might lead to a disease-modifying treatment.

    Because the ability of cartilage to heal itself decreases as we age, older people are more likely to develop the disease. Other risk factors include obesity and family history of the disease. Rheumatoid Arthritis The exact cause of rheumatoid arthritis is not known. Although it is not an inherited disease, researchers believe that some people have genes that make them more susceptible. There is usually a "trigger," such as an infection or environmental factor, which activates the genes.

    When the body is exposed to this trigger, the immune system begins to produce substances that attack the joint. Plus, they may interact with the blood thinning drug warfarin Coumadin , and glucosamine can affect blood sugar control in people with diabetes. Based on available evidence, the ACR recommends against these supplements for hip or knee OA and against glucosamine for hand OA, although evidence is more mixed for chondroitin for hand OA.

    Although one study suggested that vitamin D supplements might improve joint pain in people who are low in this nutrient, most other studies have found no significant benefit. Methylsulfonylmethane MSM MSM, a compound found in green fruits and vegetables, is used in the body to maintain and repair connective tissue, and it may have anti-inflammatory properties. Some studies found it may improve pain and function in knee OA, and a recent review says that, despite poor quality of studies, limited evidence does support using it for OA.

    Doses used in the studies ranged from 1. MSM can cause side effects, including allergic reactions. Pycnogenol Pycnogenol, a bark extract of the maritime pine, is thought to have anti-inflammatory properties.

    A systematic review found that limited evidence supports trying this for OA for a few months; studies show improvements in knee OA pain and function when taken at 50 mg two or three times daily for three months.

    Side effects may include stomach upset and increased symptoms of autoimmune diseases so talk to your doctor before trying it. Boswellia serrata This plant extract has been used in Ayurvedic medicine for centuries to treat inflammatory diseases.

    In studies, proprietary extracts of Boswellia serrata 5-Loxin, Aflapin temporarily reduced inflammation and pain and disability in knee OA. A systematic review found noteworthy effects in easing OA symptoms, although the quality of the evidence was weak.

    Minor side effects included nausea, headache, fever, diarrhea, abdominal pain and general weakness. Curcumin Curcumin, the active component that gives turmeric its distinctive yellow color, has anti-inflammatory and anti-rheumatic properties One review of studies on knee OA found that formulations of curcumin that are more easily absorbed by the body such as Theracurmin or C3 Complex reduced pain.

    VItamin D Effect on Osteoarthritis Study (VIDEO)

    More vitamin D might help if you have inflammatory arthritis. But people who have inflammatory forms of arthritis still may benefit from these supplements. Many studies and meta-analyses confirm the role of the sunshine vitamin as a powerful anti-inflammatory in rheumatoid arthritis RA and other inflammatory diseases. People with RA consistently are shown to have low levels of vitamin D.

    In fact, following injury, your body can secrete hormones that stimulate the death of your cartilage cells. Association between serum levels of hydroxyvitamin D and osteoarthritis: a systematic review Rheumatology, Volume 52, Issue 7, Pp.

    Randomized controlled trials RCTs , cohort, case—control and cross-sectional studies in adults were included. The methodological quality of the selected studies was assessed and a best-evidence synthesis was used to summarize the results due to the heterogeneity of the studies.

    Of the 86 evaluated articles, 2 RCTs and 13 observational studies were included in the final analyses. The RCTs were only reported in abstract form and showed inconsistent results, most likely due to variations in their study design. For knee radiographic OA as assessed by the Kellgren and Lawrence KL score, there was moderate evidence showing that low levels of OH D were associated with increased progression of radiographic OA.

    Strong evidence for an association between OH D and cartilage loss was apparent when joint space narrowing and changes in cartilage volume were considered collectively as cartilage loss. There is insufficient evidence for other sites. Follow this page for updates Links to this page.

    Quadriceps muscle strength was measured by dynamometry method and intensity of knee pain by Western Ontario and McMaster University Osteoarthritis index scored by Likert scale and visual analogue scale. All participants received The influence of raising serum OHD on quadriceps muscle strength and pain was assessed by calculation of mean changes from baseline at the end of the treatment period using paired t-test.

    Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial

    Osteoarthritis treatment vitamin d

    Age, body mass index, and female sex were positively associated with the prevalence. Among the dietary factors, only vitamin K intake was shown to be inversely associated with the prevalence of radiographic knee OA by multivariate logistic regression analysis.

    The presence of joint space narrowing of the knee was also inversely associated with vitamin K intake. The prevalence of radiographic knee OA for each dietary vitamin K intake quartile decreased with the increased intake.

    Vitamin K may have a protective role against knee OA and might lead to a disease-modifying treatment. Because the ability of cartilage to heal itself decreases as we age, older people are more likely to develop the disease. Other risk factors include obesity and family history of the disease. Rheumatoid Arthritis The exact cause of rheumatoid arthritis is not known. Although it is not an inherited disease, researchers believe that some people have genes that make them more susceptible.

    In , OA was estimated to affect over 1. Conventional treatment is palliative and costly, and currently there are no effective medical remedies for OA. These facts have led to being labelled the Bone and Joint decade, and musculoskeletal disorders being recognised as a National Health Priority.

    The primary task for OA management should be to identify modifiable risk factors. Vitamin D deficiency is very common in older people and has been linked with osteoporosis and falls in both older women and men. Emerging data suggests that it also plays an important role in the pathogenesis of knee OA. Side effects may include stomach upset and increased symptoms of autoimmune diseases so talk to your doctor before trying it.

    Boswellia serrata This plant extract has been used in Ayurvedic medicine for centuries to treat inflammatory diseases. In studies, proprietary extracts of Boswellia serrata 5-Loxin, Aflapin temporarily reduced inflammation and pain and disability in knee OA.

    A systematic review found noteworthy effects in easing OA symptoms, although the quality of the evidence was weak. Minor side effects included nausea, headache, fever, diarrhea, abdominal pain and general weakness. Curcumin Curcumin, the active component that gives turmeric its distinctive yellow color, has anti-inflammatory and anti-rheumatic properties One review of studies on knee OA found that formulations of curcumin that are more easily absorbed by the body such as Theracurmin or C3 Complex reduced pain.

    As with MSM, pycnogenol and Boswellia, a recent review found that limited evidence does support using it for OA, although the studies were weak. Curcumin may interact with blood thinners, such as warfarin. Some studies found ASUs improved pain, stiffness and joint function in knee and hip OA, although a recent review of studies concluded that the quality of studies was weak and improvements were modest. In certain people, ASUs can trigger an allergic reaction.

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    These findings have been validated in further studies 2 , including a comprehensive meta-analysis concluding that vitamin D levels are associated with rheumatoid arthritis activity 3. Immune system cells have vitamin D receptors, indicating immuneregulatory properties.

    Increasing vitamin D intake has been clinically shown to reduce rheumatoid arthritis symptoms, especially during winter when exposure to sunlight is typically reduced 4. Osteoarthritis Recent research has found that vitamin D has important biological functions within knee joint structures and can impact the progression of knee osteoarthritis.

    Zang and colleagues investigated serum concentrations of vitamin D hydroxyvitamin D [25 OH D] and the parathyroid hormone which regulates vitamin D in order to predict knee osteoarthritis progression 5. Researchers concluded that study participants with both low levels of vitamin D and high concentrations of parathyroid hormone had more than a 3-fold increased risk of knee osteoarthritis progression.

    Other research has found that gene polymorphisms associated with vitamin D receptors may lower immunity and increase the risk of osteoarthritis 6. However, this is controversial and more research is necessary.

    Summary Vitamin D plays an integral role in supporting healthy bones and joints. There is a clear correlation between reduced vitamin D availability and an increased risk of rheumatoid arthritis and osteoarthritis. Bibliography Merlino, L.

    Arthritis and Rheumatism. Volume 50, Issue 1, pp. Kostoglou-Athanassiou, I. Vitamin D and rheumatoid arthritis. Therapeutic Advances in Endocrinology and Metabolism. Volume 3, Issue 6. Song, G. Association between vitamin D intake and the risk of rheumatoid arthritis: meta-analysis.

    People with RA consistently are shown to have low levels of vitamin D. One study showed fewer than one-third had the minimum needed for bone health a blood level of at least 20 nanograms per milliliter. And research shows that the lowest levels are associated with more severe disease, greater disability and a worse quality of life. Does More Vitamin D Help? Manson was the lead author of a National Institutes of Health study that showed vitamin D does not protect against heart disease or cancer.

    But some rheumatologists disagree.

    One study found that people with osteoarthritis who took a vitamin D supplement had less pain and stiffness than those who did not take the supplement. Another study found that vitamin D was effective in reducing the progression of osteoarthritis.

    The exact mechanism by which vitamin D works is not fully understood, but it is thought to help reduce inflammation and promote the repair of damaged cartilage. If you are interested in trying a vitamin D supplement, speak to your doctor about whether it is right for you. Vitamin D supplements are available over the counter at most pharmacies. It is important to take the supplement as directed and to have your vitamin D levels checked and monitored regularly.

    Why not opt for a convenient Vitamin D home test kit? Related: What is a vitamin D test? Are there any side effects associated with taking vitamin D supplements for treating osteoarthritis symptoms? The most common side effect of taking vitamin D supplements is nausea. Other side effects can include headache, constipation, and fatigue. Vitamin D is a safe and effective treatment for osteoarthritis symptoms, but it is important to speak to your doctor before starting any new supplement.

    Vitamin D is just one of many treatments that can help improve the symptoms of osteoarthritis. In addition to taking supplements, you can also help reduce your symptoms by losing weight, exercising regularly, and avoiding activities that put stress on your joints. If you are living with osteoarthritis, talk to your doctor about what treatments are right for you. What are some tips for living well with osteoarthritis, including exercises that can be done to help keep the joints mobile and flexible?

    There is no cure for osteoarthritis, but there are a number of things you can do to help manage the symptoms. These include: Exercising regularly: Exercise can help improve joint function and reduce pain. It is important to choose low-impact exercises that do not put too much stress on the joints.

    Losing weight: If you are overweight, losing even a small amount of weight can help reduce the symptoms of osteoarthritis. Avoiding activities that put stress on the joints: If certain activities make your symptoms worse, try to avoid them or do them less often. Protecting the joints: Use heat or cold therapy, braces, or other devices to protect the joints from further damage. Recently we have demonstrated that baseline serum levels of hydroxy-vitamin D OH D predicts change in cartilage volume in older adults over 2 years, and increases in vitamin D levels are associated with a further protective association.

    This suggests that vitamin D supplementation may enhance cartilage and bone health, and thus prevent disease progression in patients with knee OA.

    The aim of this study is to compare the effects of vitamin D supplementation versus placebo on knee pain and knee structural changes in patients with symptomatic knee osteoarthritis over a 2- year period. The proposed study design is a randomised, placebo-controlled, double-blind clinical trial. All participants will be provided recommended standard of care. Knee structural changes including knee cartilage volume, cartilage defects, tibial bone area, bone marrow lesions, and meniscal pathology assessed by MRI , and knee pain at baseline and 2 years later will be determined as outcome measures.

    Other explanatory factors, such as serum vitamin D levels, height, weight, physical activity, and smoking will also be determined through study period. Significance: Observational evidence suggests that vitamin D deficiency may have a role in the progression of OA and there are biologically plausible mechanisms to explain this.

    However, randomized controlled trials using a sensitive method are required to determine whether intervening with vitamin D supplementation can in fact slow the progression of this disease. In this study, the randomized, placebo-controlled, double-blind design, and the use of MRI to provide sensitive and precise measures of knee structural change will ensure a rigorous evaluation of the impact of vitamin D supplementation on knee OA.

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